CLEVELAND, OHIO – (December 28, 2021) – MALACHITE INNOVATIONS, INC. (OTC Mkts:
MLCT) announces that its wholly-owned drug development subsidiary, Graphium Biosciences, Inc., has
been granted two patents by the U.S. Patent and Trademark Office (USPTO) for its cannabinoid glycoside
prodrug, and has filed a new patent under the Patent Cooperation Treaty (PCT) for its novel
manufacturing process used to produce its proprietary cannabinoid glycosides. The Company’s new patent
application was filed with the USPTO and preserves our right to seek patent protection in 153 foreign
nations that are signatories of the PCT.

Granted: Cannabinoid Glycoside Prodrugs and Methods of Synthesis
Graphium Biosciences has been granted a patent by the USPTO for its “Cannabinoid Glycoside Prodrugs
and Methods of Synthesis” that involves its invention of cannabinoid glycosides and methods of targeted
delivery for the treatment of gastrointestinal disorders, including inflammatory bowel disease (IBD) and
irritable bowel syndrome (IBS). Based on our PCT application filed in 2016, our granted patent covers the
first 18 distinct cannabinoid glycosides based on cannabidiol (CBD), tetrahydrocannabinol (THC),
cannabidivarin (CBDV), and cannabinol (CBN), and serves as the cornerstone of our intellectual property
portfolio of cannabinoid prodrugs. Graphium Biosciences is also pursuing additional claims and patent
rights through divisional applications for this patent.

IBD, which includes Crohn’s disease and ulcerative colitis, is a chronic inflammatory disease of the
gastrointestinal tract characterized by periods of remissions and flares. Currently, IBD is a debilitating
condition with no cure and is estimated to affect more than 3 million people in the United States. IBS is a
non-inflammatory condition that affects the function and behavior of the intestines, often resulting in
cramping, abdominal pain and other challenging gastrointestinal issues. IBS is a chronic condition with
no cure and is estimated to affect between 25 and 45 million people in the United States.

Granted: Antimicrobial Composition Comprising Cannabinoids and Methods of Using the Same
Graphium Biosciences has been granted a patent by the USPTO for its “Antimicrobial Composition
Comprising Cannabinoids and Methods of Using the Same” for the use of cannabinoids as antibiotics for
the treatment of Clostridiodes difficile (C. diff). Based on our PCT application filed in 2018, our granted
patent covers the use of cannabidiol (CBD) or tetrahydrocannabinol (THC) for the treatment of infections
by C.diff, E. faecalis, S. pneumoniae, and others. Graphium Biosciences is also pursuing additional claims
and patent rights through division applications for this patent.
 
C. diff is responsible for almost 500,000 illnesses and nearly 30,000 deaths each year in the United States.
C. diff is also a known cause of colitis, so this antimicrobial patent complements our cannabinoid
glycoside patents. The granted patent also covers the use of cannabinoids as antimicrobials against
Vancomycin-resistant enterobacteriaceae (VRE), an infection responsible for more than 55,000 hospital-
related infections and over 5,000 deaths per year in the United States. The granted patent also covers the
use of cannabinoids as antimicrobials against S. pneumoniae, the leading cause of bacterial pneumoniae
and meningitis in the United States.

New Filing: Continuous Enzymatic Perfusion Reactor System
Graphium Biosciences filed a new patent entitled “Continuous Enzymatic Perfusion Reactor System”
under the PCT covering its novel reactor and manufacturing process that results in a significant
improvement of our glycoside production, a key manufacturing step in our cannabinoid glycoside
manufacturing process.
 
Dr. Brandon Zipp, Chief Science Officer, stated “Our cannabinoid glycoside patent filed in 2016 is the
earliest patent describing any novel cannabinoid glycosides, and therefore, the USPTO’s recent granting
of our novel and innovative patent serves as a key milestone in our drug development program. The
granting of this patent solidifies our position as pioneers in the field of unlocking the therapeutic benefits
of cannabinoids without psychoactive side effects.” Dr. Zipp continued, “Receiving patent grants for our
core cannabinoid glycosides and for cannabinoids as antimicrobials addressing the challenging infections
C. diff and VRE is a great addition to our growing intellectual property portfolio and further validates our
innovation-driven R&D program.”

About Malachite Innovations, Inc.
Headquartered in Cleveland, Ohio, Malachite Innovations, Inc. is an innovative socially-conscious
company dedicated to improving the health and wellness of people and our planet. Malachite deploys this
dual, interconnected strategy through two wholly-owned operating subsidiaries. Graphium Biosciences,
our operating subsidiary dedicated to improving the health and wellness of people, seeks to advance our
broad portfolio of over 100 novel cannabinoid-glycoside compounds created using our proprietary
enzymatic bioprocessing technologies to develop safe and effective novel treatments for chronic and
debilitating conditions, with an initial focus on inflammatory bowel disease. Daedalus Ecosciences, our
operating unit dedicated to improving the health and wellness of our planet, seeks to identify, invest in
and reposition challenging environmental situations with a particular focus on technological innovations
and eco-friendly solutions deployed in economically challenged communities.

Notice Regarding Forward-Looking Statements
This press release contains “forward-looking statements” as that term is defined in Section 27(a) of the
Securities Act of 1933, as amended and Section 21(e) of the Securities Exchange Act of 1934, as
amended. Statements in this press release which are not purely historical are forward-looking statements
and include any statements regarding beliefs, plans, expectations or intentions regarding the future.
Although we believe that these statements are based on reasonable assumptions, they are subject to
numerous factors that could cause actual outcomes and results to be materially different from those
indicated in such statements. Such factors include, among others, the inherent uncertainties associated
with new projects and development stage companies, timing of clinical trials and product development,
business strategy and new lines of business. These forward-looking statements are made as of the date of
this press release, and we assume no obligation to update the forward-looking statements, or to update the
reasons why actual results could differ from those projected in the forward-looking statements. Although
we believe that any beliefs, plans, expectations and intentions contained in this press release are
reasonable, there can be no assurance that any such beliefs, plans, expectations or intentions will prove to
be accurate. Investors should consult all of the information set forth herein and should also refer to the
risk factors disclosure outlined in our annual report on Form 10-K for the most recent fiscal year, our
quarterly reports on Form 10-Q and other periodic reports filed from time-to-time with the Securities and
Exchange Commission.


 
Malachite Innovations, Inc.
Investor Relations
P: +1 (216) 304-6556
E: [email protected]
W: www.malachiteinnovations.com

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